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Article

QTQTN motif upstream of the furin-cleavage site plays a key role in SARS-CoV-2 infection and pathogenesis

26 Jul 2022

Abstract excerpt

The furin cleavage site (FCS), an unusual feature in the SARS-CoV-2 spike protein, has been spotlighted as a factor key to facilitating infection and pathogenesis by increasing spike processing. Similarly, the QTQTN motif directly upstream of the FCS is also an unusual feature for group 2B coronaviruses (CoVs). The QTQTN deletion has consistently been observed in in vitro cultured virus stocks and some clinical...

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PMID: 35881779
DOI: 10.1073/pnas.2205690119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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