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Article

Retrotransposon instability dominates the acquired mutation landscape of mouse induced pluripotent stem cells.

Nature communications - 3 Dec 2022

Gerdes Patricia, Lim Sue Mei, Ewing Adam D, Larcombe Michael R, Chan Dorothy, Sanchez-Luque Francisco J, Walker Lucinda, Carleton Alexander L, James Cini, Knaupp Anja S, Carreira Patricia E, Nefzger Christian M, Lister Ryan, Richardson Sandra R, Polo Jose M, Faulkner Geoffrey J

Abstract excerpt

Induced pluripotent stem cells (iPSCs) can in principle differentiate into any cell of the body, and have revolutionized biomedical research and regenerative medicine. Unlike their human counterparts, mouse iPSCs (miPSCs) are reported to silence transposable elements and prevent transposable element-mediated mutagenesis. Here we apply short-read or Oxford Nanopore Technologies long-read genome sequencing to 38...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36463236
DOI: 10.1038/s41467-022-35180-x
PMCID: PMC9719517

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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