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Article

Retinoid-X-Receptor as a Mediator of Poststroke Recovery by Reversing Age-Associated Phenotypes of Microglia/Hematogenous Macrophages.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 10 Sept 2025

Ting Shun-Ming, Zhao Xiurong, Sun Guanghua, Ricote Mercedes, Aronowski Jaroslaw

Abstract excerpt

After stroke, microglia and hematogenous macrophages, together referred to as MΦ, clear dead cells and cellular debris in the infarcted brain through phagocytosis as an essential part of the recovery process. However, the phagocytic capability of MΦ declines with age. Furthermore, aged MΦ become overactivated in response to stroke, enhancing secondary brain injury. In this study, we demonstrated that by reversing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40803891
DOI: 10.1523/JNEUROSCI.0248-25.2025
PMCID: PMC12424960

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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