Article
Retinoic acid isomers facilitate apolipoprotein E production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway.
The Journal of biological chemistry - 18 Apr 2014
Zhao Jing, Fu Yuan, Liu Chia-Chen, Shinohara Mitsuru, Nielsen Henrietta M, Dong Qiang, Kanekiyo Takahisa, Bu Guojun
Abstract excerpt
Apolipoprotein E (apoE) is the major cholesterol transport protein in the brain. Among the three human APOE alleles (APOE2, APOE3, and APOE4), APOE4 is the strongest genetic risk factor for late-onset Alzheimer disease (AD). The accumulation of amyloid-β (Aβ) is a central event in AD pathogenesis. Increasing evidence demonstrates that apoE isoforms differentially regulate AD-related pathways through both...
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