Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Liver X receptor agonist treatment significantly affects phenotype and transcriptome of APOE3 and APOE4 Abca1 haplo-deficient mice.

PloS one - 1 Jan 2017

Carter Alexis Y, Letronne Florent, Fitz Nicholas F, Mounier Anais, Wolfe Cody M, Nam Kyong Nyon, Reeves Valerie L, Kamboh Hafsa, Lefterov Iliya, Koldamova Radosveta

Abstract excerpt

ATP-binding cassette transporter A1 (ABCA1) controls cholesterol and phospholipid efflux to lipid-poor apolipoprotein E (APOE) and is transcriptionally controlled by Liver X receptors (LXRs) and Retinoic X Receptors (RXRs). In APP transgenic mice, lack of Abca1 increased Aβ deposition and cognitive deficits. Abca1 haplo-deficiency in mice expressing human APOE isoforms, increased level of Aβ oligomers and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein E3
Share to ATP Binding Cassette Transporter 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Haploinsufficiency

Share to Liver X Receptors

Share to Maze Learning

Share to Memory Disorders

Share to Microtubules

Source

Open in PubMed Open full text

Identifiers

PMID: 28241068
DOI: 10.1371/journal.pone.0172161
PMCID: PMC5328633

Genes

APP
APOE
ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Liver X receptor agonist treatment significantly affects phenotype and transcriptome of APOE3 and APOE4 Abca1 haplo-deficient mice.PMID 28241068Read ↗

Role of LXR and ABCA1 in the Pathogenesis of Alzheimers Disease -Implications for a New Therapeutic ApproachSemantic proximity Read ↗

Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice.Semantic proximity Read ↗

ABCA1 Agonist Reverses the ApoE4-Driven Cognitive and Brain PathologiesSemantic proximity Read ↗

Retinoic acid isomers facilitate apolipoprotein E production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway.Semantic proximity Read ↗

Expression of Liver X Receptor Target Genes Decreases Cellular Amyloid β Peptide SecretionSemantic proximity Read ↗

Liver-X receptor β-selective agonist CE9A215 regulates Alzheimer’s disease- associated pathology in a 3xTg-AD mouse modelSemantic proximity Read ↗

The role of ATP-binding cassette transporter A1 in Alzheimer's disease and neurodegeneration.Semantic proximity Read ↗

Brain single-cell transcriptional responses to bexarotene-activated RXR in Alzheimer’s disease modelSemantic proximity Read ↗

Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo.Semantic proximity Read ↗

Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptorsSemantic proximity Read ↗

Rexinoids as Therapeutics for Alzheimer's Disease: Role of APOESemantic proximity Read ↗

RXR controlled regulatory networks identified in mouse brain counteract deleterious effects of Aβ oligomersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.