Article

Interdependent regulation of trabecular meshwork cell physiology and intraocular pressure by KALRN and TMCO1

2025-09-21

Abstract excerpt

Glaucoma is a leading cause of irreversible blindness. Primary open-angle glaucoma (POAG) is its most common form. Higher intraocular pressure (IOP), resulting from impaired aqueous humour outflow, is the cardinal mediating factor, and all proven treatments aim to lower IOP. POAG is a complex genetic disease with numerous loci linked to POAG and higher IOP. The mechanisms by which risk alleles cause disease remain...

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Literature Corpus work: d0d8a221-f94c-509d-8e80-0401162a4492
DOI: 10.1101/2025.09.19.677310

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