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Article

High throughput functional profiling of genes at intraocular pressure loci reveals distinct networks for glaucoma.

Human molecular genetics - 18 Apr 2024

Greatbatch Connor J, Lu Qinyi, Hung Sandy, Barnett Alexander J, Wing Kristof, Liang Helena, Han Xikun, Zhou Tiger, Siggs Owen M, Mackey David A, Cook Anthony L, Senabouth Anne, Liu Guei-Sheung, Craig Jamie E, MacGregor Stuart, Powell Joseph E, Hewitt Alex W

Abstract excerpt

INTRODUCTION: Primary open angle glaucoma (POAG) is a leading cause of blindness globally. Characterized by progressive retinal ganglion cell degeneration, the precise pathogenesis remains unknown. Genome-wide association studies (GWAS) have uncovered many genetic variants associated with elevated intraocular pressure (IOP), one of the key risk factors for POAG. We aimed to identify genetic and morphological...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38272457
DOI: 10.1093/hmg/ddae003
PMCID: PMC11031357

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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