Article
Genetic association and stress mediated down-regulation in trabecular meshwork implicates MPP7 as a novel candidate gene in primary open angle glaucoma.
BMC medical genomics - 22 Mar 2016
Vishal Mansi, Sharma Anchal, Kaurani Lalit, Alfano Giovanna, Mookherjee Suddhasil, Narta Kiran, Agrawal Jyoti, Bhattacharya Iman, Roychoudhury Susanta, Ray Jharna, Waseem Naushin H, Bhattacharya Shomi S, Basu Analabha, Sen Abhijit, Ray Kunal, Mukhopadhyay Arijit
Abstract excerpt
BACKGROUND: Glaucoma is the largest cause of irreversible blindness affecting more than 60 million people globally. The disease is defined as a gradual loss of peripheral vision due to death of Retinal Ganglion Cells (RGC). The RGC death is largely influenced by the rate of aqueous humor production by ciliary processes and its passage through the trabecular meshwork (TM) in the anterior part of the eye. Primary...
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