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Myocilin Gene Mutation Induced Autophagy Activation Causes Dysfunction of Trabecular Meshwork Cells

9 May 2022

Abstract excerpt

Trabecular meshwork dysfunction is the main cause of primary open angle glaucoma (POAG) associated with elevated intraocular pressure (IOP). Mutant myocilin causes glaucoma mainly via elevating IOP. Previously we have found that accumulated Asn 450 Tyr (N450Y) mutant myocilin impairs human trabecular meshwork (TM) cells by inducing chronic endoplasmic reticulum (ER) stress response in vitro. However, it is...

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PMID: 35615698
DOI: 10.3389/fcell.2022.900777

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Related research

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Myocilin Gene Mutation Induced Autophagy Activation Causes Dysfunction of Trabecular Meshwork CellsPMID 35615698Read ↗

Accumulation of Asn450Tyr mutant myocilin in ER promotes apoptosis of human trabecular meshwork cells.Semantic proximity Read ↗

Serine to proline mutation at position 341 of MYOC impairs trabecular meshwork function by causing autophagy deregulationSemantic proximity Read ↗

MYOC/p.G367R mutation induces cell dysfunction of the trabecular meshwork and retina via impairment of the protein degradation mechanismSemantic proximity Read ↗

Serine to proline mutation at position 341 of MYOC impairs trabecular meshwork function by causing autophagy deregulationSemantic proximity Read ↗

Autophagic dysregulation in glaucomatous trabecular meshwork cellsSemantic proximity Read ↗

Somatic Mutations within Myocilin due to Aging May Be a Potential Risk Factor for Glaucoma.Semantic proximity Read ↗

Accumulation of mutant myocilins in ER leads to ER stress and potential cytotoxicity in human trabecular meshwork cells.Semantic proximity Read ↗

Somatic Mutations within Myocilin due to Aging may be a Potential Risk Factor for Glaucoma.Semantic proximity Read ↗

Expression of Mutant Myocilin Induces Abnormal Intracellular Accumulation of Selected Extracellular Matrix Proteins in the Trabecular Meshwork.Semantic proximity Read ↗

Cellular processing of myocilin.Semantic proximity Read ↗

Pro370Leu mutant myocilin impairs mitochondrial functions in human trabecular meshwork cells.Semantic proximity Read ↗

Structural basis for anomalous cellular trafficking behavior of glaucoma-associated A427T mutant myocilinSemantic proximity Read ↗

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