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TAZ ( <i>Wwtr1</i> ) deficiency leads to ER stress and mitochondrial dysfunction in a mouse model of Fuchs’ endothelial corneal dystrophy

2026-02-19

Abstract excerpt

Fuchs’ endothelial corneal dystrophy (FECD) impacts over 300 million individuals worldwide with corneal transplantation as the primary treatment. There is a dire need to establish non-surgical alternatives which are dependent on mouse models. Transcriptional co-activator with PDZ-binding motif (TAZ, encoded by Wwtr1 ) is a mechanotransducer implicated in maintaining homeostasis of corneal endothelial cells (CEnC)...

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Literature Corpus work
5a7ac0c0-eacc-5e93-952c-ccaedf277026
DOI
10.64898/2026.02.17.706456
Open publication

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