Article

Serine to proline mutation at position 341 of MYOC impairs trabecular meshwork function by causing autophagy deregulation

2023-07-14

Abstract excerpt

<title>Abstract</title> <p>Glaucoma is a highly heritable disease and myocilin was the first identified causal gene and most common pathogenic gene in glaucoma. Serine to proline mutation at position 341 of myocilin (MYOC<sup>S341P</sup>) is associated with severe glaucoma phenotypes in a five generation of primary open angle glaucoma family. But the underlying mechanisms is under explored. Here, we established M...

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Literature Corpus work: eba1f249-3981-5e91-b58e-fb0658b203be
DOI: 10.21203/rs.3.rs-3126933/v1

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