Article

Transcriptomic Atlas of Human Trabecular Meshwork Uncovers the Cellular Landscape and Provides Insights into Glaucoma Pathophysiology

2026-06-22

Abstract excerpt

<title>Abstract</title> <p>The trabecular meshwork (TM) is a specialized multicellular tissue that regulates aqueous humor outflow and intraocular pressure (IOP), and its dysfunction is a central driver of glaucoma. However, how cellular states and molecular mechanisms of TM cell populations are altered in human glaucoma remains poorly understood. Here, we present a comprehensive single-nucleus transcriptomic atl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9e972bd5-a701-5773-ab63-1272a3f3657a
DOI: 10.21203/rs.3.rs-9540265/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptomic Atlas of Human Trabecular Meshwork Uncovers the Cellular Landscape and Provides Insights into Glaucoma PathophysiologyDOI 10.21203/rs.3.rs-9540265/v1Read

Molecular taxonomy of human ocular outflow tissues defined by single cell transcriptomicsSemantic proximity Read

Genome-wide transcriptome profiling of human trabecular meshwork cells treated with TGF-β2Semantic proximity Read

Genome-Wide Transcriptome Profiling of Human Trabecular Meshwork Cells Treated with TGF-β2.Semantic proximity Read

Single-cell transcriptomic Atlas of aging macaque ocular outflow tissuesSemantic proximity Read

An Integrated muti-omics cell atlas of the human trabecular meshwork and ciliary bodySemantic proximity Read

Molecular taxonomy of human ocular outflow tissues defined by single-cell transcriptomicsSemantic proximity Read

To be or not to be - Decoding the Trabecular Meshwork Cell IdentitySemantic proximity Read

Cell atlas of trabecular meshwork in glaucomatous non-human primates and DEGs related to tissue contract based on single-cell transcriptomicsSemantic proximity Read

Transcriptomic Profiling of High vs. Low Flow Regions of Mouse and Human Trabecular MeshworkSemantic proximity Read

High throughput functional profiling of genes at intraocular pressure loci reveals distinct networks for glaucoma.Semantic proximity Read

Integrative Transcriptomic Analysis of Anterior and Posterior IOP-Controlling Tissues in Glaucoma Reveals Enrichment of MHC-II Pathway and T-Cell Infiltration SignaturesSemantic proximity Read

Genome-Wide RNA Sequencing of Human Trabecular Meshwork Cells Treated with TGF-β1: Relevance to Pseudoexfoliation GlaucomaSemantic proximity Read