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Article

COMPASS: joint copy number and mutation phylogeny reconstruction from amplicon single-cell sequencing data.

Nature communications - 15 Aug 2023

Sollier Etienne, Kuipers Jack, Takahashi Koichi, Beerenwinkel Niko, Jahn Katharina

Abstract excerpt

Reconstructing the history of somatic DNA alterations can help understand the evolution of a tumor and predict its resistance to treatment. Single-cell DNA sequencing (scDNAseq) can be used to investigate clonal heterogeneity and to inform phylogeny reconstruction. However, most existing phylogenetic methods for scDNAseq data are designed either for single nucleotide variants (SNVs) or for large copy number...

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Identifiers

PMID: 37582954
DOI: 10.1038/s41467-023-40378-8
PMCID: PMC10427627

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