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Transcriptional Programs following Genetic Alterations in p53 , INK4A , and H-Ras Genes along Defined Stages of Malignant Transformation

1 Jun 2005

Abstract excerpt

The difficulty to dissect a complex phenotype of established malignant cells to several critical transcriptional programs greatly impedes our understanding of the malignant transformation. The genetic elements required to transform some primary human cells to a tumorigenic state were described in several recent studies. We took the advantage of the global genomic profiling approach and tried to go one step...

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PMID: 15930270
DOI: 10.1158/0008-5472.can-04-3880

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