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Article

Lineage Plasticity and Histologic Transformation in EGFR-TKI Resistant Lung Cancer.

International journal of molecular sciences - 31 Dec 2025

Lau Li Yieng Eunice, Skanderup Anders Jacobsen, Tan Aaron C

Abstract excerpt

Lineage plasticity, the ability of cancer cells to alter their differentiated state through transcriptional and epigenetic reprogramming, has emerged as a key mechanism of therapeutic resistance across cancers. This adaptive process can manifest in multiple ways, including epithelial-mesenchymal transition, acquisition of stem-like features, and histological transformation, the most striking and clinically...

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Share to Cell Lineage
Share to Cell Transformation, Neoplastic
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to ErbB Receptors

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Source

Open in PubMed Open full text

Identifiers

PMID: 41516316
DOI: 10.3390/ijms27010445
PMCID: PMC12785988

Genes

EGFR

Provenance

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