Article
Lineage Plasticity and Histologic Transformation in EGFR-TKI Resistant Lung Cancer.
International journal of molecular sciences - 31 Dec 2025
Lau Li Yieng Eunice, Skanderup Anders Jacobsen, Tan Aaron C
Abstract excerpt
Lineage plasticity, the ability of cancer cells to alter their differentiated state through transcriptional and epigenetic reprogramming, has emerged as a key mechanism of therapeutic resistance across cancers. This adaptive process can manifest in multiple ways, including epithelial-mesenchymal transition, acquisition of stem-like features, and histological transformation, the most striking and clinically...
Topics
- Humans
- ErbB Receptors
- Lung Neoplasms
- Drug Resistance, Neoplasm
- Protein Kinase Inhibitors
- Cell Transformation, Neoplastic
- Mutation
- Animals
- Cell Lineage
- Epigenesis, Genetic