Article

The comprehensive roadmaps of reprogramming and transformation unveiled antagonistic roles for bHLH transcription factors in the control of cellular plasticity

2020-12-28

Abstract excerpt

Coordinated changes of cellular identity and plasticity are critical for pluripotent reprogramming (PR) and malignant transformation (MT). However, the molecular circuitries orchestrating these modifications, as well as their degree of analogy during reprogramming and transformation, remain unknown. To address this question, we generated “repro-transformable” mice models and dissected comparatively the early event...

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Literature Corpus work: 8194d6ae-b4a2-54b8-b4a7-16d5fbe2c270
DOI: 10.1101/2020.12.28.424606

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