Article

Epigenetic mechanisms controlling human leukemia stem cells and therapy resistance

2022-09-22

Abstract excerpt

Many human cancers, including acute myeloid leukemia (AML), arise from mutations of stem and progenitor cells. Immunophenotypic profiling has shown that leukemias develop hierarchically, with mutations in leukemia stem cells associated with disease propagation and relapse 1,2 . Although leukemia initiating cells can be enriched using cell surface markers, their frequency tends to be variable and low, obscuring me...

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Literature Corpus work: d0a2c248-2ed1-581b-83bb-3ed47a77c365
DOI: 10.1101/2022.09.22.509005

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