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Article

Single-cell analysis of acute lymphoblastic and lineage-ambiguous leukemia: approaches and molecular insights

4 Aug 2022

Abstract excerpt

Despite recent progress in identifying the genetic drivers of acute lymphoblastic leukemia (ALL), prognosis remains poor for those individuals who experience disease recurrence. Moreover, acute leukemias of ambiguous lineage lack a biologically informed framework to guide classification and therapy. These needs have driven the adoption of multiple complementary single-cell sequencing approaches to explore key...

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PMID: 35926109
DOI: 10.1182/blood.2022016954

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