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Article

Eradication of Leukemia Stem Cells as a New Goal of Therapy in Leukemia

15 Jan 2006

Abstract excerpt

Leukemias have traditionally been classified and treated on the basis of phenotypic characteristics, such as morphology and cell-surface markers, and, more recently, cytogenetic aberrations. These classification systems are flawed because they do not take into account cellular function. The leukemia cell population is functionally heterogeneous: it consists of leukemia stem cells (LSC) and mature leukemia cells...

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PMID: 16428470
DOI: 10.1158/1078-0432.ccr-05-1879

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