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Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells.

Cell reports - 2 Jun 2020

Wesely Josephine, Kotini Andriana G, Izzo Franco, Luo Hanzhi, Yuan Han, Sun Jun, Georgomanoli Maria, Zviran Asaf, Deslauriers André G, Dusaj Neville, Nimer Stephen D, Leslie Christina, Landau Dan A, Kharas Michael G, Papapetrou Eirini P

Abstract excerpt

Leukemia stem cells (LSCs) are believed to have more distinct vulnerabilities than the bulk acute myeloid leukemia (AML) cells, but their rarity and the lack of universal markers for their prospective isolation hamper their study. We report that genetically clonal induced pluripotent stem cells (iPSCs) derived from an AML patient and characterized by exceptionally high engraftment potential give rise, upon...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32492433
DOI: 10.1016/j.celrep.2020.107688
PMCID: PMC7786450

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