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Epigenetic mechanisms controlling human leukemia stem cells and therapy resistance

3 Apr 2025

Abstract excerpt

Cancer stem cells are essential for initiation and therapy resistance of many cancers, including acute myeloid leukemias (AML). Here, we apply functional genomic profiling to diverse human leukemias, including high-risk MLL- and NUP98-rearranged specimens, using label tracing in vivo. Human leukemia propagation is mediated by a rare quiescent label-retaining cell (LRC) population undetectable by current...

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PMID: 40180954
DOI: 10.1038/s41467-025-58370-9

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