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Flagellum and toxin phase variation impacts intestinal colonization and disease development in a mouse model of Clostridioides <i>difficile</i> infection

2021-09-29

Abstract excerpt

Clostridioides difficile is a major nosocomial pathogen that can cause severe, toxin-mediated diarrhea and pseudomembranous colitis. Recent work has shown that C. difficile exhibits heterogeneity in swimming motility and toxin production in vitro through phase variation by site-specific DNA recombination. The recombinase RecV reversibly inverts the flagellar switch sequence upstream of the flgB operon, leading...

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Literature Corpus work
d084fd1d-9d76-5f2e-a3ce-98161cfaeae0
DOI
10.1101/2021.09.29.462200
Open publication

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Flagellum and toxin phase variation impacts intestinal colonization and disease development in a mouse model of Clostridioides <i>difficile</i> infectionDOI 10.1101/2021.09.29.462200
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