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Flagellar switch inverted repeats impact heterogeneity in flagellar gene expression and thus C. difficile RT027/MLST1 virulence

1 Jun 2025

Abstract excerpt

Clostridioides difficile (C. difficile) RT027 strains cause infections that vary in severity from asymptomatic to lethal, but the molecular basis for this variability is poorly understood. Through comparative analyses of RT027 clinical isolates, we determine that isolates that exhibit greater heterogeneity in their flagellar gene expression exhibit greater virulence in vivo. C. difficile flagellar genes are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40504685
DOI: 10.1016/j.celrep.2025.115830

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