Article
Phase variation of a signal transduction system controls Clostridioides difficile colony morphology, motility, and virulence.
PLoS biology - 1 Oct 2019
Garrett Elizabeth M, Sekulovic Ognjen, Wetzel Daniela, Jones Joshua B, Edwards Adrianne N, Vargas-Cuebas Germán, McBride Shonna M, Tamayo Rita
Abstract excerpt
Recent work has revealed that Clostridioides difficile, a major cause of nosocomial diarrheal disease, exhibits phenotypic heterogeneity within a clonal population as a result of phase variation. Many C. difficile strains representing multiple ribotypes develop two colony morphotypes, termed rough and smooth, but the biological implications of this phenomenon have not been explored. Here, we examine the molecular...
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