Back to search

Article

Control of <i>Clostridiodes difficile</i> virulence and physiology by the flagellin homeostasis checkpoint FliC-FliW-CsrA in the absence of motility

2022-11-08

Abstract excerpt

<h4>ABSTRACT</h4> Mutations affecting Clostridioides difficile flagellin (FliC) have been shown to be hypervirulent in animal models and display increased toxin production and alterations in central metabolism. The regulation of flagellin levels in bacteria is governed by a tripartite regulatory network involving fliC , fliW , and csrA , which creates a feedback system to regulate flagella production. Through...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c362590c-e672-5d12-bf84-1c1f3ad03d41
DOI
10.1101/2022.11.08.515568
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Control of <i>Clostridiodes difficile</i> virulence and physiology by the flagellin homeostasis checkpoint FliC-FliW-CsrA in the absence of motilityDOI 10.1101/2022.11.08.515568
Control of Clostridioides difficile virulence and physiology by the flagellin homeostasis checkpoint FliC-FliW-CsrA in the absence of motility.Semantic proximity
FliW and CsrA govern flagellin (FliC) synthesis and play pleiotropic roles in virulence and physiology of <i>Clostridioides difficile</i> R20291Semantic proximity
FliW and CsrA Govern Flagellin (FliC) Synthesis and Play Pleiotropic Roles in Virulence and Physiology of Clostridioides difficile R20291Semantic proximity
Dissecting the Role of Flagellar Subunits in <i>C. difficile</i> Mucosal ColonizationSemantic proximity
The Role of Flagella in Clostridium difficile Pathogenesis: Comparison between a Non-Epidemic and an Epidemic StrainSemantic proximity
Flagellar switch inverted repeat impacts flagellar invertibility and varies <i>Clostridioides difficile</i> RT027/MLST1 virulenceSemantic proximity
Characterization of flagellar and toxin phase variation in <i>Clostridium difficile</i> ribotype 012 isolatesSemantic proximity
RstA Regulation of <i>Clostridioides difficile</i> Toxin Production and Sporulation in Phenotypically Diverse StrainsSemantic proximity
Dissecting the role of flagellar subunits in C. difficile mucosal colonization.Semantic proximity
Anti-σ <sup>28</sup> factor FlgM secretion regulates <i>Vibrio cholerae</i> adaptability in adult mice through quorum sensing and methionine metabolismSemantic proximity
A genetic switch controls the production of flagella and toxins in Clostridium difficileSemantic proximity
The role of flagella in Clostridium difficile pathogenicity.Semantic proximity
Select a neighboring publication to make it the new centre.