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Article

Phase variable colony morphotypes of Clostridioides difficile elicit distinct host responses during acute infection.

Infection and immunity - 14 Jul 2026

Santos-Santiago Jilarie A, Gadda Nicole C, Sellers Rani S, Tamayo Rita

Abstract excerpt

Many Clostridioides difficile strains can form two colony morphotypes: rough and smooth. The rough and smooth morphotypes differ in multiple phenotypes, including cell length and chaining, motility, biofilm production, and virulence in the hamster model of C. difficile infection (CDI). Colony morphology undergoes phase variation and is determined by the ON/OFF expression of cmrRST, which encodes a signal...

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Identifiers

PMID: 42262088
DOI: 10.1128/iai.00022-26
PMCID: PMC13367059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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