Article

Phase variable colony morphotypes of <i>Clostridioides difficile</i> elicit distinct host responses during acute infection

2026-01-11

Abstract excerpt

<h4>ABSTRACT</h4> Many Clostridioides difficile strains can form two colony morphotypes: rough and smooth. The rough and smooth morphotypes differ in multiple phenotypes, including cell length and chaining, motility, biofilm production, and virulence in the hamster model of C. difficile infection (CDI). Colony morphology undergoes phase variation and is determined by the ON/OFF expression of cmrRST , which enc...

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Literature Corpus work: 15a70097-d3e2-5139-bb43-7e22aff6df51
DOI: 10.64898/2026.01.09.698580

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