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Characterization of Flagellum and Toxin Phase Variation in Clostridioides difficile Ribotype 012 Isolates

8 May 2018

Abstract excerpt

ABSTRACT Clostridioides difficile causes diarrheal diseases mediated in part by the secreted toxins TcdA and TcdB. C. difficile produces flagella that also contribute to motility and bacterial adherence to intestinal cells during infection. Flagellum expression and toxin gene expression are linked via the flagellar alternative sigma factor, SigD. Recently, we identified a flagellar switch upstream of the early...

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PMID: 29735765
DOI: 10.1128/jb.00056-18

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