Article

Machine learning guided signal enrichment for ultrasensitive plasma tumor burden monitoring

2022-01-20

Abstract excerpt

<h4>ABSTRACT</h4> In solid tumor oncology, circulating tumor DNA (ctDNA) is poised to transform care through accurate assessment of minimal residual disease (MRD) and therapeutic response monitoring. To overcome the sparsity of ctDNA fragments in low tumor fraction (TF) settings and increase MRD sensitivity, we previously leveraged genome-wide mutational integration through plasma whole genome sequencing (WGS). W...

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Literature Corpus work: d07b8e96-41b0-569e-87ec-6941b4ec4677
DOI: 10.1101/2022.01.17.476508

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