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Evaluation of cell-free DNA approaches for multi-cancer early detection

17 Nov 2022

Abstract excerpt

In the Circulating Cell-free Genome Atlas (NCT02889978) substudy 1, we evaluate several approaches for a circulating cell-free DNA (cfDNA)-based multi-cancer early detection (MCED) test by defining clinical limit of detection (LOD) based on circulating tumor allele fraction (cTAF), enabling performance comparisons. Among 10 machine-learning classifiers trained on the same samples and independently validated, when...

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PMID: 36400018
DOI: 10.1016/j.ccell.2022.10.022

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