Article

Fragle: Universal ctDNA quantification using deep learning of fragmentomic profiles

2023-07-28

Abstract excerpt

Quantification of circulating tumor DNA (ctDNA) levels in blood enables non-invasive surveillance of cancer progression. Fragle is an ultra-fast deep learning-based method for ctDNA quantification directly from cell-free DNA fragment length profiles. We developed Fragle using low-pass whole genome sequence (lpWGS) data from multiple cancer types and healthy control cohorts, demonstrating high accuracy, and improve...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dbe91991-8c3d-517e-b2dc-67fdeebda74b
DOI: 10.1101/2023.07.28.550922

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Fragle: Universal ctDNA quantification using deep learning of fragmentomic profilesDOI 10.1101/2023.07.28.550922Read

Combining mutation detection with fragmentomics features leads to improved tumor-informed ctDNA detectionSemantic proximity Read

Ultra-low coverage fragmentomic model of cell-free DNA for cancer detection based on whole-exome regionsSemantic proximity Read

Systematic benchmarking of multi-modal approaches for tumor-naïve ctDNA detection and quantificationSemantic proximity Read

Ultrasensitive plasma-based monitoring of tumor burden using machine-learning-guided signal enrichment.Semantic proximity Read

Machine learning guided signal enrichment for ultrasensitive plasma tumor burden monitoringSemantic proximity Read

Deep learning-based non-invasive profiling of tumor transcriptomes from cell-free DNA for precision oncologySemantic proximity Read

Analytical and Clinical Validation of Cell-Free Circulating Tumor DNA Assay for the Estimation of Tumor Mutational Burden.Semantic proximity Read

Tumor-naïve ctDNA detection with deep learning-enhanced error suppression for sensitive mutation calling.Semantic proximity Read

Somatic copy number alteration and fragmentation analysis in circulating tumor DNA for cancer screening and treatment monitoring in colorectal cancer patients.Semantic proximity Read

Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring.Semantic proximity Read

A deep-learning model for quantifying circulating tumour DNA from the density distribution of DNA-fragment lengthsSemantic proximity Read

Leveraging sequences missing from the human genome to diagnose cancerSemantic proximity Read