Article
ctDNA monitoring using patient-specific sequencing and integration of variant reads.
Science translational medicine - 17 Jun 2020
Wan Jonathan C M, Heider Katrin, Gale Davina, Murphy Suzanne, Fisher Eyal, Mouliere Florent, Ruiz-Valdepenas Andrea, Santonja Angela, Morris James, Chandrananda Dineika, Marshall Andrea, Gill Andrew B, Chan Pui Ying, Barker Emily, Young Gemma, Cooper Wendy N, Hudecova Irena, Marass Francesco, Mair Richard, Brindle Kevin M, Stewart Grant D, Abraham Jean E, Caldas Carlos, Rassl Doris M, Rintoul Robert C, Alifrangis Constantine, Middleton Mark R, Gallagher Ferdia A, Parkinson Christine, Durrani Amer, McDermott Ultan, Smith Christopher G, Massie Charles, Corrie Pippa G, Rosenfeld Nitzan
Abstract excerpt
Circulating tumor-derived DNA (ctDNA) can be used to monitor cancer dynamics noninvasively. Detection of ctDNA can be challenging in patients with low-volume or residual disease, where plasma contains very few tumor-derived DNA fragments. We show that sensitivity for ctDNA detection in plasma can be improved by analyzing hundreds to thousands of mutations that are first identified by tumor genotyping. We describe...
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