Article

Vδ2 T cell activation by malaria is enhanced in second infection via the cell extrinsic cytokine milieu

2026-05-01

Abstract excerpt

γδ T cells play critical roles in innate immunity to Plasmodium falciparum malaria, yet their functional heterogeneity and memory-like dynamics during first and subsequent infections remain poorly defined. Using longitudinal single-cell RNA sequencing, ex vivo phenotyping and in vitro functional analysis of γδ T cells in controlled human malaria infection (CHMI), we dissect their activation mechanisms and funct...

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Literature Corpus work: d06d0b68-b56d-5a34-b42d-adf57f3585a4
DOI: 10.64898/2026.04.29.26352021

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