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Hepatic γδ NKT cells modulate liver-resident CD8+ T cells to attenuated malaria parasite vaccines

2026-08-25

Abstract excerpt

Plasmodium parasites develop in the liver and egress to infect red blood cells, causing malaria. Vaccines that generate hepatic CD8+ T cells eliminate liver-stage parasites and prevent disease, yet how these T cells are induced is incompletely understood. We report that in mice vaccinated with replication-competent genetically attenuated Plasmodium parasites, antagonism of γδ T cell function curtails protection. V...

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Identifiers and source

Literature Corpus work
eccf9c78-343f-53e7-b1ea-53434816e42f
DOI
10.64898/2026.08.21.746325
Open publication

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Hepatic γδ NKT cells modulate liver-resident CD8+ T cells to attenuated malaria parasite vaccinesDOI 10.64898/2026.08.21.746325
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