Article

Cytotoxic Vδ2+ T cell subsets expand in response to malaria in human tonsil and spleen organoids

2025-09-27

Abstract excerpt

Vaccine effectiveness against malaria is dramatically reduced in malaria-exposed compared to malaria-naïve populations, potentially due to altered immune responses in secondary lymphoid organs following repeated infection. Newly developed human tonsil and spleen organoids, which replicate key features of B and T cell immunity, provide an exciting opportunity to overcome challenges of other models and to improve ou...

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Literature Corpus work: 5ba5b3ce-a6b6-5845-8cbe-1986dc00a4c7
DOI: 10.1101/2025.09.24.678447

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