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Article

Human hypoblast formation is not dependent on FGF signalling

1 Nov 2011

Abstract excerpt

Mouse embryos segregate three different lineages during preimplantation development: trophoblast, epiblast and hypoblast. These differentiation processes are associated with restricted expression of key transcription factors (Cdx2, Oct4, Nanog and Gata6). The mechanisms of segregation have been extensively studied in the mouse, but are not as well characterised in other species. In the human embryo, hypoblast...

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PMID: 22079695
DOI: 10.1016/j.ydbio.2011.10.030

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