Article

Gastrulation-stage gene expression in <i>Nipbl</i> <sup>+/-</sup> mouse embryos foreshadows the development of syndromic birth defects

2023-10-17

Abstract excerpt

In animal models, Nipbl -deficiency phenocopies gene expression changes and birth defects seen in Cornelia de Lange Syndrome (CdLS), the most common cause of which is Nipbl -haploinsufficiency. Previous studies in Nipbl +/- mice suggested that heart development is abnormal as soon as cardiogenic tissue is formed. To investigate this, we performed single-cell RNA-sequencing on wildtype (WT) and Nipbl +/- mous...

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Literature Corpus work: 8cb5f751-a5a9-5ebf-91ed-3fa8292b233d
DOI: 10.1101/2023.10.16.558465

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