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Article

Oct4 regulates the embryonic axis and coordinates exit from pluripotency and germ layer specification in the mouse embryo.

Development (Cambridge, England) - 18 Jun 2018

Mulas Carla, Chia Gloryn, Jones Kenneth Alan, Hodgson Andrew Christopher, Stirparo Giuliano Giuseppe, Nichols Jennifer

Abstract excerpt

Lineage segregation in the mouse embryo is a finely controlled process dependent upon coordination of signalling pathways and transcriptional responses. Here we employ a conditional deletion system to investigate embryonic patterning and lineage specification in response to loss of Oct4. We first observe ectopic expression of Nanog in Oct4-negative postimplantation epiblast cells. The expression domains of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29915126
DOI: 10.1242/dev.159103
PMCID: PMC6031404

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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