Article

Data-driven model reveals increased stability of CAG-expanded <i>huntingtin</i> RNA due to MID1 binding

2025-11-01

Abstract excerpt

RNA-binding proteins (RBP) are important regulators of RNA metabolism. In neurode-generative disorders such as Huntington’s Disease (HD), disrupted RBP-RNA interactions contribute to neuronal dysfunction. One such RBP, Midline 1 (MID1), has been shown to aberrantly associate with mutant huntingtin ( Htt ) RNA, enhancing its translation, yet the mechanism driving this effect remains unknown. Here, we develop a com...

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Literature Corpus work: d05e6db0-b2cf-51a5-ac8f-61d2b08845c1
DOI: 10.1101/2025.10.31.685889

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