Article

m6A RNA modification of m <i>Htt</i> intron 1 regulates the generation of <i>Htt1a</i> in Huntington’s Disease

2023-11-10

Abstract excerpt

<h4>ABSTRACT</h4> Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder caused by an expanded, somatically unstable CAG repeat in the first exon of the huntingtin gene ( HTT) . In the presence of an expanded CAG repeat, huntingtin mRNA undergoes an aberrant processing that generates HTT1a transcripts with exon 1 and intron 1 sequences, which encodes the aggregation-prone and pathogenic...

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Literature Corpus work: 24bd0aaa-4c16-581a-9d34-6c45b619d1e2
DOI: 10.1101/2023.11.10.566530

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