Article

Sequence-sensitive elastic network captures dynamical features necessary for miR-125a maturation

2022-06-10

Abstract excerpt

The Elastic Network Contact Model (ENCoM) is a coarse-grained normal mode analysis (NMA) model unique in its all-atom sensitivity to the sequence of the studied macromolecule and thus to the effect of mutations. We adapted ENCoM to simulate the dynamics of ribonucleic acid (RNA) molecules, benchmarked its performance against other popular NMA models and used it to study the 3D structural dynamics of human microRNA...

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Literature Corpus work: a6cfeb4b-f8ba-52da-b0b9-5c722e4c0cb5
DOI: 10.1101/2022.06.09.495567

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