Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SUPT4H1 Depletion Leads to a Global Reduction in RNA

1 Jan 2019

Abstract excerpt

SUPT4H1 is a transcription elongation factor that makes up part of the RNA polymerase II complex. Recent studies propose a selective role for SUPT4H1 in the transcription of repeat-containing DNA, the translated products of which contribute to neurodegenerative disorders such as C9orf72-amyotrophic lateral sclerosis. To investigate the potential of SUPT4H1 as a therapeutic target in repeat-associated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Muscle Physiology and Disorders
Share to Neurogenetic and Muscular Disorders Research
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30605685
DOI: 10.1016/j.celrep.2018.12.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SUPT4H1 Depletion Leads to a Global Reduction in RNAPMID 30605685Read ↗

ZC3H4 restricts non-coding transcription in human cellsSemantic proximity Read ↗

Spt4 selectively regulates the expression of <i>C9orf72</i> sense and antisense mutant transcriptsSemantic proximity Read ↗

IGHMBP2 deletion suppresses translation and activates the integrated stress responseSemantic proximity Read ↗

Mismatch repair dissection by in vivo RNAi reveals dose-dependent modulators of somatic instability and proteome remodeling in Huntington’s diseaseSemantic proximity Read ↗

The RNA helicase DHX36/G4R1 modulates <i>C9orf72</i> GGGGCC repeat-associated translationSemantic proximity Read ↗

A CTG repeat-selective chemical screen identifies microtubule inhibitors as selective modulators of toxic CUG RNA levelsSemantic proximity Read ↗

Defective Integrator activity shapes the transcriptome of patients with multiple sclerosisSemantic proximity Read ↗

Small molecule inhibition of multiple RNA binding proteins underlies Musashi-2 independent phenotypesSemantic proximity Read ↗

Chemical interference with DSIF complex formation lowers synthesis of mutant huntingtin gene products and curtails mutant phenotypes.Semantic proximity Read ↗

Genetic alterations in SUPT6H are associated with neurodevelopmental disorders.Semantic proximity Read ↗

GAA•TTC repeat expansion in human cells is mediated by mismatch repair complex MutLγ and depends upon the endonuclease domain in MLH3 isoform oneSemantic proximity Read ↗

Data-driven model reveals increased stability of CAG-expanded <i>huntingtin</i> RNA due to MID1 bindingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.