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Article

Pharmacological disruption of the MID1/α4 interaction reduces mutant Huntingtin levels in primary neuronal cultures.

Neuroscience letters - 23 Apr 2018

Monteiro Olivia, Chen Changwei, Bingham Ryan, Argyrou Argyrides, Buxton Rachel, Pancevac Jönsson Christina, Jones Emma, Bridges Angela, Gatfield Kelly, Krauß Sybille, Lambert Jeremy, Langston Rosamund, Schweiger Susann, Uings Iain

Abstract excerpt

Expression of mutant Huntingtin (HTT) protein is central to the pathophysiology of Huntington's Disease (HD). The E3 ubiquitin ligase MID1 appears to have a key role in facilitating translation of the mutant HTT mRNA suggesting that interference with the function of this complex could be an attractive therapeutic approach. Here we describe a peptide that is able to disrupt the interaction between MID1 and the α4...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29499308
DOI: 10.1016/j.neulet.2018.02.061

Genes

HTT
MID1
TAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pharmacological disruption of the MID1/α4 interaction reduces mutant Huntingtin levels in primary neuronal cultures.PMID 29499308Read ↗

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