Article

DNA-binding specificity recognition from predicted homologous protein-DNA structures

2026-06-17

Abstract excerpt

Predicting protein DNA-binding specificity is essential for understanding gene regulation and disease mechanisms. Existing deep learning methods typically infer specificity from a single protein-DNA complex structure, which limits their ability to capture the diverse geometric patterns underlying protein-DNA recognition. Homologous protein-DNA interfaces provide complementary structural evidence and richer geometr...

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Literature Corpus work: d058259a-f1ce-5409-90ac-7c209c56bbc4
DOI: 10.64898/2026.06.16.732781

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