Article

Integrating Protein and DNA Embeddings for Improving Genome-Wide Transcription Factor Binding Site Prediction

2025-09-17

Abstract excerpt

Transcription factors (TFs) regulate gene expression by binding to specific DNA sites on genome, making accurate TF binding site prediction critical for understanding gene regulation and downstream phenotypes. Current deep learning methods use only DNA-related information to predict TF binding sites, ignoring the fact that different TF protein sequences and structures recognize distinct DNA patterns. Not leveragin...

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Literature Corpus work: 83871f86-9c5b-5a56-9b24-917c601ebea0
DOI: 10.1101/2025.09.15.676319

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