Article

HydRA: Deep-learning models for predicting RNA-binding capacity from protein interaction association context and protein sequence

2022-12-23

Abstract excerpt

RNA-binding proteins (RBPs) control RNA metabolism to orchestrate gene expression, and dysfunctional RBPs underlie many human diseases. Proteome-wide discovery efforts predict thousands of novel RBPs, many of which lack canonical RNA-binding domains. Here, we present a hybrid ensemble RBP classifier (HydRA) that leverages information from both intermolecular protein interactions and internal protein sequence patte...

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Literature Corpus work: c29f75a6-db85-59f6-a96e-9ed91e24fcb8
DOI: 10.1101/2022.12.23.521837

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