Article

Frequent Aneuploidy in Primary Human T Cells Following CRISPR-Cas9 cleavage

2021-08-20

Abstract excerpt

<h4>SUMMARY</h4> Multiple ongoing clinical trials use site-specific nucleases to disrupt T cell receptor (TCR) genes in order to allow for allogeneic T cell therapy 1–5 . In particular, the first U.S. clinical trial using CRISPR-Cas9 entailed the targeted disruption of the TCR chains and programmed cell death protein 1 (PDCD1) in T cells of refractory cancer patients 6 . Here, we used the same guide RNA sequenc...

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Literature Corpus work: d029b80b-49bf-5d7d-9130-7f5407fd7c5a
DOI: 10.1101/2021.08.20.457092

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