Article

Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells

2023-03-22

Abstract excerpt

<h4>Summary</h4> CRISPR-Cas9 genome editing has enabled advanced T cell therapies, but occasional loss of the targeted chromosome remains a safety concern. To investigate whether Cas9-induced chromosome loss is a universal phenomenon and evaluate its clinical significance, we conducted a systematic analysis in primary human T cells. Arrayed and pooled CRISPR screens revealed that chromosome loss was generalizable...

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Literature Corpus work: 7eb58ec8-eb32-5597-bd7b-c499adcbbf73
DOI: 10.1101/2023.03.22.533709

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