Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells

1 Oct 2023

Abstract excerpt

CRISPR-Cas9 genome editing has enabled advanced T cell therapies, but occasional loss of the targeted chromosome remains a safety concern. To investigate whether Cas9-induced chromosome loss is a universal phenomenon and evaluate its clinical significance, we conducted a systematic analysis in primary human T cells. Arrayed and pooled CRISPR screens revealed that chromosome loss was generalizable across the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to CRISPR and Genetic Engineering
Share to Pluripotent Stem Cells Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37794590
DOI: 10.1016/j.cell.2023.08.041

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cellsPMID 37794590Read ↗

Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cellsSemantic proximity Read ↗

Preventing large deletions and chromosome loss in engineered human primary T cells by CasPlus with optimized guide RNAsSemantic proximity Read ↗

Frequent Aneuploidy in Primary Human T Cells Following CRISPR-Cas9 cleavageSemantic proximity Read ↗

Frequent aneuploidy in primary human T cells after CRISPR–Cas9 cleavageSemantic proximity Read ↗

Applications of CRISPR Genome Editing to Advance the Next Generation of Adoptive Cell Therapies for CancerSemantic proximity Read ↗

Engineering the next-generation of CAR T-cells with CRISPR-Cas9 gene editingSemantic proximity Read ↗

Increasing Gene Editing Efficiency via CRISPR/Cas9- or Cas12a-Mediated Knock-In in Primary Human T CellsSemantic proximity Read ↗

CRISPR-Cas9 Causes Chromosomal Instability and Rearrangements in Cancer Cell Lines, Detectable by Cytogenetic Methods.Semantic proximity Read ↗

The CRISPR-Cas12a Platform for Accurate Genome Editing, Gene Disruption, and Efficient Transgene Integration in Human Immune CellsSemantic proximity Read ↗

Detection and Modulation of DNA Translocations During Multi-Gene Genome Editing in T CellsSemantic proximity Read ↗

Building Potent Chimeric Antigen Receptor T Cells With CRISPR Genome EditingSemantic proximity Read ↗

Single-cell multiplex approaches deeply map ON-target CRISPR-genotoxicity and reveal its mitigation by palbociclib and long-term engraftment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.