Article

Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors

2018-11-29

Abstract excerpt

Chimeric antigen receptor engineered T cell (CAR-T) immunotherapy has shown efficacy against a subset of hematological malignancies 1,2 , yet its autologous nature and ineffectiveness against epithelial and solid cancers limit widespread application. To overcome these limitations, targeted nucleases have been used to disrupt checkpoint inhibitors and genes involved in alloreactivity 3–6 . However, the production...

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Literature Corpus work: cb5acde8-e61c-5c16-a289-4efcbf0b57e0
DOI: 10.1101/482497

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